TRPM8 antagonist 2
TRPM8 antagonist 2
CAS: 259674-19-6
Molecular Formula: C26H26N2O2
TRPM8 antagonist 2 - Names and Identifiers
TRPM8 antagonist 2 - Physico-chemical Properties
| Molecular Formula | C26H26N2O2 |
| Molar Mass | 398.5 |
| Density | 1.195±0.06 g/cm3(Predicted) |
| Boling Point | 567.5±50.0 °C(Predicted) |
| Solubility | DMSO : 160 mg/mL (401.51 mM; Need ultrasonic) |
| pKa | 17.02±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | TRPM8 antagonist 2 is an effective, selective TRPM8 antagonist with an IC50 value of 0.2 nM and can be used to study neuropathic pain syndrome. |
| In vitro study | TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist, with an IC 50 of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 antagonist 2 potently inhibits menthol-induced increase in intracellular Ca 2+ levels in Ca 2+ fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC 50 , 40 nM). |
| In vivo study | TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice. |
TRPM8 antagonist 2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.509 ml | 12.547 ml | 25.094 ml |
| 5 mM | 0.502 ml | 2.509 ml | 5.019 ml |
| 10 mM | 0.251 ml | 1.255 ml | 2.509 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.502 ml |
Last Update：2024-01-02 23:10:35
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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